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# GATE 2018 Syllabus for Biotechnology (BT)

Last Updated - August 19, 2017

Biotechnology is covered in various engineering branches like Bioinformatics, Biomedical engineering and in biotechnology itself. Exam pattern for GATE Biotechnology is same as that of Biomedical and Bioinformatics. GATE will be conducted in online mode as a Computer Based Test and will have multiple-choice questions. Candidates will be given 3 hours to complete the exam.

• GATE 2018 is scheduled for February 03, 04, 10 and 11, 2018.
• GATE Exam Pattern consists of 3 sections namely General Aptitude, Engineering Mathematics and specific subject of the paper.
• A proper GATE Paper Analysis must be done by the candidates about the sections are covered in the exams and must exclude the unworthy sections.
• GATE Biotechnology Syllabus will include Engineering Mathematics, Biotechnology, Recombinant DNA Technology, Plant and Animal Biotechnology and Bioprocess Engineering and Process Biotechnology.

GATE Exam Pattern will consist of total 65 questions and a candidate can score maximum 100 marks in the exam. No marks will be deducted for any wrong answer. GATE will be held in 2 shifts (Morning and Afternoon).

It is very important for a candidate to know the GATE 2017 Exam Pattern so that he or she can know the type and number of questions asked in the exam.

### GATE Biotechnology Syllabus 2018

GATE 2018 for Biotechnology program will have questions from topics such as Engineering Mathematics, Biotechnology, Recombinant DNA Technology, Plant and Animal Biotechnology and Bioprocess Engineering and Process Biotechnology. to study these topics, candidates can refer to the best Preparation Books for GATE

Section-wise syllabus of GATE 2018 is explained below.

#### Section. 1 Engineering Mathematics

TopicsSub-Topics
Linear AlgebraMatrices and determinants, Systems of linear equations, Eigen values and Eigen vectors
CalculusLimit, continuity and differentiability, Partial derivatives, Maxima and minima, Sequences and series, Test for convergence, Fourier series
Differential EquationsLinear and nonlinear first order ODEs, higher order ODEs with constant coefficients, Cauchy's and Euler's equations, Laplace transforms, PDE- Laplace, heat, and wave equations
Probability and StatisticsMean, median, mode and standard deviation, Random variables, Poisson, normal and binomial distributions, Correlation and regression analysis
Numerical MethodsSolution of linear and nonlinear algebraic equations, Integration of trapezoidal and Simpson's rule, Single and multi-step methods for differential equation

#### Section. 2 Biotechnology

TopicsSub-Topics
MicrobiologyProkaryotic and eukaryotic cell structure; Microbial nutrition, growth, and control; Microbial metabolism (aerobic and anaerobic respiration, photosynthesis); Nitrogen fixation; the Chemical basis of mutations and mutagens; Microbial genetics (plasmids, transformation, transduction, conjugation); Microbial diversity and characteristic features; Viruses.
BiochemistryBiomolecules and their conformation; Weak inter-molecular interactions in biomacromolecules; Chemical and functional nature of enzymes; Kinetics of a single substrate and bi-substrateenzyme-catalyzedd reactions; Bioenergetics; Metabolism (Glycolysis, TCA, and Oxidative phosphorylation); Membrane transport and pumps; Cell cycle and cell growth control; Cell signaling and signal transduction.
Molecular Biology and GeneticsMolecular structure of genes and chromosomes; DNA replication and control; Transcription and its control; Translational processes; Regulatory controls in prokaryotes and eukaryotes; Mendelian inheritance; Gene interaction; Complementation; Linkage, recombination and chromosome mapping; Extrachromosomal inheritance; Chromosomal variation; Population genetics; Transposable elements, Molecular basis of genetic diseases and applications.
Analytical TechniquesPrinciples of microscopy-light, electron, fluorescent and confocal; Centrifugation- high-speed and ultra; Principles of spectroscopy-UV, visible, CD, IR, FTIR, Raman, MS, NMR; Principles of chromatography- ion exchange, gel filtration, hydrophobic interaction, affinity, GC, HPLC, FPLC; Electrophoresis; Microarray
ImmunologyThe origin of Immunology; Inherent immunity; Humoral and cell-mediated immunity; Primary and secondary lymphoid organ; Antigen; B and T cells and Macrophages; Major histocompatibility complex (MHC); Antigen processing and presentation; Synthesis of antibody and secretion; Molecular basis of antibody diversity; Polyclonal and monoclonal antibody; Complement; Antigen-antibody reaction; Regulation of immune response; Immune tolerance; Hypersensitivity; Autoimmunity; Graft versus host reaction.
BioinformaticsMajor Bioinformatics resources (NCBI, EBI, ExPASy); Sequence and structure databases; Sequence analysis (Bio-molecular sequence file formats, scoring matrices, sequence alignment, phylogeny); Genomics and Proteomics (Large-scale genome sequencing strategies; Comparative genomics; Understanding DNA microarrays and protein arrays); Molecular modeling and simulations (basic concepts including concept of force fields)

#### Section. 3 Recombinant DNA Technology

Restriction and modification enzymes; Vectors: plasmid, bacteriophage and other viral vectors, cosmids, Ti plasmid, yeast artificial chromosome; cDNA and genomic DNA library; Gene isolation; Gene cloning; Expression of cloned gene; Transposons and gene targeting; DNA labeling; DNA sequencing; Polymerase chain reactions; DNA fingerprinting; Southern and northern blotting; In- situ hybridization; RAPD; RFLP; Site-directed mutagenesis; Gene transfer technologies; Gene therapy.

#### Section. 4 Plant and Animal Biotechnology

• Totipotency Regeneration of plants; Plant growth regulators and elicitors; Tissue culture and Cell suspension culture system: methodology, kinetics of growth and, nutrient optimization; Production of secondary metabolites by plant suspension cultures; Hairy root culture; transgenic plants; Plant products of industrial importance Animal cell culture; media composition and growth conditions;
• Animal cell and tissue preservation; Anchorage and non-anchorage dependent cell culture; Kinetics of cell growth; Micro & macro-carrier culture; Hybridoma technology; Stem cell technology; Animal cloning; Transgenic animals

#### Section. 5 Bioprocess Engineering and Process Biotechnology

• Chemical engineering principles applied to biological system, Principle of reactor design, ideal and non-ideal multiphase bioreactors, mass and heat transfer
• Rheology of fermentation fluids, Aeration and agitation; Media formulation and optimization; Kinetics of microbial growth, substrate utilization and product formation; Sterilization of air and media; Batch, fed-batch and continuous processes; various types of microbial and enzyme reactors; Instrumentation control and optimization; Unit operations in solid-liquid separation and liquid-liquid extraction; Process scale-up, economics and feasibility analysis
• Engineering principle of bioprocessing- Upstream production and downstream; Bioprocess design and development from lab to industrial scale; Microbial, animal and plant cell culture platforms; Production of biomass and primary/secondary metabolites; Biofuels, Bio-plastics, industrial enzymes, antibiotics; Large scale production and purification of recombinant proteins; Industrial application of chromatographic and membrane based bio-separation methods; Immobilization of biocatalysts (enzymes and cells) for bioconversion processes; Bioremediation-Aerobic and anaerobic processes for stabilization of solid / liquid wastes

As there will be different papers for various disciplines, so candidates must solve GATE Practice Papers to focus on understanding for a comprehensive preparation.help the aspirants to score well in the exam.

### GATE 2018 Previous Year Papers for Biotechnology

It is very important for a candidate to practice GATE 2018 Previous Year Papersfor Biotechnologyso that they can idea regarding the type of questions asked in the exam. It also helps in improving the speed of the candidate. The candidate must practice using a stop watch to improve the speed. Take a note of the mistakes done and try not to repeat them again.

 Sample Paper 1 for Biotechnology (BT) Sample Paper 2 for Biotechnology (BT)

Recommended Books for GATE 2018

Candidates can practice from some of the best books recommended for GATE 2018 mentioned below:

• GATE 2018 Guide Biotechnology (Author-G.K.P; Publisher- G.K. Publisher)
• Biotechnology GATE 2018 (Author-B.M. Agarwal, Akanksha Singhal, Vidhika Goel; Publisher-Arihant Publications)
• Biotechnology for CSIR- NET, SET, GATE, JNU, AIIMS, JAM (Author-Vinita Thakur; Publisher- Himalaya Publication House)

GATE 2018 exam will have Virtual Calculator for the candidates for making calculation during the exam. Apart from practicing previous years’ papers, candidates must also learn to use  It was first introduced last year for the candidates as they brought a physical calculator for making calculations during the exam and also to reduce the chances of cheating through unfair means.

### Syllabus Of Other Papers

GATE judges a candidate’s expertise in specific fields. Candidates can go through the syllabus of other papers as well from the table below:

PaperCodePaperCode
Aerospace EngineeringAEMechanical EngineeringME
Agricultural EngineeringAGMetallurgical EngineeringMT
Civil EngineeringCEMining EngineeringMN
Chemical EngineeringCHPetroleum EngineeringPE
Computer Science and Information TechnologyCSProduction and Industrial EngineeringPI
Electronics and CommunicationECTextile Engineering and Fibre ScienceTF
Electrical EngineeringEEEngineering SciencesXE
Instrumentation EngineeringIN

sumit kumar

I m expecting 52 in gate 2018 civil and m belong to sc category.. Can I get any PSU?

15 Mar, 2018 10:56
Sakshi Garg Expert

Hi Sumit, You get information about the GATE Cutoff list through this link: PSU Cutoff List.

21 Mar, 2018 12:12
Prashant kumar

Sir my gate marks 65 in gate 2018 in civil engineering can I get it Delhi?

14 Mar, 2018 02:37
Sakshi Garg Expert

Hi Prashant, Please check the Cutoff list of Delhi through this link: GATE Delhi Cutoff

17 Mar, 2018 11:20
Avinash Chauhan

I m expecting 32 number in gate 2018 mechanical and belong to sc category can i get admisiion in dtu??

09 Mar, 2018 00:22
Sakshi Garg Expert

Hi Avinash, I am giving you the Cutoff list of DTU college please check the list through this link: GATE Cutoff List.

09 Mar, 2018 12:58
sama raju

what is the expected cut off marks for physics ( OBC Category)

23 Feb, 2018 13:53
Sakshi Garg Expert

Hi Sama, To get information about the Cutoff by this link: GATE Cutoff List

23 Feb, 2018 16:04

how much mark is required to get admission in iit kharakpur..

16 Feb, 2018 21:16
Sakshi Garg Expert

Hi Arvind, I am giving you the Cutoff list of IIT Kharagpur please check the list through this link: Gate Cutoff List

17 Feb, 2018 15:19
abhishek sharma

I am from commerce background and I have done MBA with specialization in hr can I eligible for filling the form for the post of personal and hr pls rep me fast

30 Jan, 2018 11:05
Sakshi Garg Expert

Hi Abhishek, GATE (Graduate Aptitude Test in Engineering) is a national level test for admission to M.Tech/ Ph.D. and other Government Scholarships/Assistantships in the field of engineering and technology. So you can not fill this exam for MBA. But you can apply for MBA by filling the CAT, XAT, CMAT, GMAT entrance exam.

15 Feb, 2018 16:34
suraj rohila

how to prepare for gate and when we will get the forms of gate exam and now a i am in fourth year

15 Jun, 2017 00:20
Kalpana Sharma Expert

Hi Suraj, The GATE 2018 Online Application Processing System (GOAPS) website opens from September 01, 2017. You can check form status from the official website. For know about the preparing tips, please check this link Prepare for GATE

01 Sep, 2017 18:24
NIKHIL SAHU

about nsr round in ccmt 2017

12 Apr, 2017 00:20

Hi Nikhil, to get details on GATE counseling and its rounds, please find the link http://exams.collegedunia.com/gate/counselling

12 Apr, 2017 17:03
Sumitra chakraborty

plz tell me gate exam 2017 when will be held

24 Mar, 2017 11:06

Hi Sumitra, GATE 2017 Examination has been completed, you may apply for GATE 2018.To get details on GATE 2018, please find the link http://exams.collegedunia.com/news/e-60-gate-2018

24 Mar, 2017 11:19
kanivarshini

GATE exam updtes and cut off for colleges in Tamilnadu

06 Mar, 2017 11:59
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